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Clopidogrel 75 mg generico precio, levitra, or nateglinide other antihypertensive therapy. In patients with hypertension, use of antihypertensive therapy is recommended. Use in Patients with Pre-existing Liver Disease Liver function tests are generally recommended. The dose should be reduced if the results Generic drug atorvastatin of initial liver function tests are abnormal or persistently elevated. Use in Patients with Renal Impairment As with all medications, the renal efficacy of diuretics (including used to treat hypertension) is not fully established. Use of diuretics should be restricted to situations in which there is a clear need for rapid elimination or when there are no alternative measures of renal function (e.g. urine output, creatinine clearance) available. Pregnancy Pregnancy Category C The use of diuretics in pregnant women has not been approved by the FDA as a method of preventing stillbirth. The safety diuretics during pregnancy has not been established. Nonclinical Toxicology Carcinogenesis, Mutagenesis, Impairment of Fertility Carcinogenesis Data are insufficient to establish a carcinogenic potential of diuretic drugs. Mutagenesis Folic acid, the active metabolite of diuretic, has been determined to be an inactive mutagen, and no deleterious effects on the chromosome (deoxyribonucleic acid) structure have been observed in vitro and vivo studies with this metabolite [see Drug Interactions (7.2) and (7.3)]. Impairment of Fertility There are insufficient data to establish a specific risk male fertility with use of diuretics. The safety of diuretics as used for the treatment clopidogrel buy online of hypertension at any gestational age has not been established. Pediatric Use Safety and efficacy of diuretics (including used to treat hypertension) have not been established in pediatric patients. Geriatric Use Clinical trials using diuretics in elders have been conducted primarily in patients aged 65 and older have not conclusively demonstrated an increased risk for adverse reactions or decreased hepatic and renal function. Geriatric patients are at increased risk for adverse drug reactions and should be monitored appropriately. No evidence exists that diuretics cause cancer. No mutagenic effect has been reported in vitro or vivo mice rats, in vitro human cell lines or tissues. There are no data in the literature to reflect a potential negative effect on fertility in elderly women. It is not known whether diuretics cause fetal harm when administered to pregnant women. Breast-feeding Data are insufficient to establish whether diuretics are harmful to breast-feeding infants. Safety and efficacy for diuretics are not established in pediatric patients due to the limited available data. Folic acid, the active metabolite of diuretic, has been determined to be a significant inactive mutagen. No deleterious effects on the chromosome (deoxyribonucleic acid) structure have been observed in vitro and vivo studies with this metabolite in human cell lines or tissues. The safety of diuretics as used for the treatment of hypertension at any gestational age has not been established. The risks and benefits of using diuretics during pregnancy have not been established. The effects of diuretics on spermatogenesis and testes function have not been established. There are no data in the literature to reflect a potential negative effect on fertility in.



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